Human centromere repositioning activates transcription and opens chromatin fibre structure

Catherine Naughton; Covadonga Huidobro; Claudia R. Catacchio; Adam Buckle; Graeme R. Grimes; Ryu-Suke Nozawa; Stefania Purgato; Mariano Rocchi; Nick Gilbert

doi:10.1038/s41467-022-33426-2

Nature Communications (Sep 2022)

Human centromere repositioning activates transcription and opens chromatin fibre structure

Catherine Naughton,
Covadonga Huidobro,
Claudia R. Catacchio,
Adam Buckle,
Graeme R. Grimes,
Ryu-Suke Nozawa,
Stefania Purgato,
Mariano Rocchi,
Nick Gilbert

Affiliations

Catherine Naughton: MRC Human Genetics Unit, The University of Edinburgh
Covadonga Huidobro: MRC Human Genetics Unit, The University of Edinburgh
Claudia R. Catacchio: MRC Human Genetics Unit, The University of Edinburgh
Adam Buckle: MRC Human Genetics Unit, The University of Edinburgh
Graeme R. Grimes: MRC Human Genetics Unit, The University of Edinburgh
Ryu-Suke Nozawa: MRC Human Genetics Unit, The University of Edinburgh
Stefania Purgato: MRC Human Genetics Unit, The University of Edinburgh
Mariano Rocchi: Department of Biology, University of Bari
Nick Gilbert: MRC Human Genetics Unit, The University of Edinburgh

DOI: https://doi.org/10.1038/s41467-022-33426-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

In this study, using a human neocentromere as a model, the authors show that centromeres have a special chromatin structure. Centromere repositioning triggers transcriptional activation, epigenetic remodelling and chromatin fibre decompaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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