Nature Communications (Oct 2022)
Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma
- Katrin Rabold,
- Martijn Zoodsma,
- Inge Grondman,
- Yunus Kuijpers,
- Manita Bremmers,
- Martin Jaeger,
- Bowen Zhang,
- Willemijn Hobo,
- Han J. Bonenkamp,
- Johannes H. W. de Wilt,
- Marcel J. R. Janssen,
- Lenneke A. M. Cornelissen,
- Ilse C. H. van Engen-van Grunsven,
- Willem J. M. Mulder,
- Jan W. A. Smit,
- Gosse J. Adema,
- Mihai G. Netea,
- Yang Li,
- Cheng-Jian Xu,
- Romana T. Netea-Maier
Affiliations
- Katrin Rabold
- Department of Internal Medicine, Radboud University Medical Center
- Martijn Zoodsma
- Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
- Inge Grondman
- Department of Internal Medicine, Radboud University Medical Center
- Yunus Kuijpers
- Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
- Manita Bremmers
- Department of Haematology, Radboud University Medical Center
- Martin Jaeger
- Department of Internal Medicine, Radboud University Medical Center
- Bowen Zhang
- Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
- Willemijn Hobo
- Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center
- Han J. Bonenkamp
- Department of Surgery, Radboud University Nijmegen Medical Centre
- Johannes H. W. de Wilt
- Department of Surgery, Radboud University Nijmegen Medical Centre
- Marcel J. R. Janssen
- Department of Radiology and Nuclear Medicine, Radboud University Nijmegen Medical Centre
- Lenneke A. M. Cornelissen
- Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center
- Ilse C. H. van Engen-van Grunsven
- Department of Pathology, Radboud University Nijmegen Medical Centre
- Willem J. M. Mulder
- Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai
- Jan W. A. Smit
- Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center
- Gosse J. Adema
- Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center
- Mihai G. Netea
- Department of Internal Medicine, Radboud University Medical Center
- Yang Li
- Department of Internal Medicine, Radboud University Medical Center
- Cheng-Jian Xu
- Department of Internal Medicine, Radboud University Medical Center
- Romana T. Netea-Maier
- Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-33907-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Myeloid cells contribute to the tumor microenvironment of thyroid cancers, but their functional relevance is lesser known. Here authors show that myeloid cells infiltrating non-medullary thyroid carcinomas upregulate their antigen presentation-related genes, release less cytokines and over-produce reactive oxygen species, with transcriptional changes already present in extra-tumoral myeloid cells.
