The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology

Zhang Hui; Zhu Fei-Yue; He Xiao-Juan; Tang Shi-Huan; Long Ting; Peng Lu; Zhang Hong-Mei; Zou Zong-Zhi; Xiong Zhu; Zhang Xian-Ping

doi:10.1515/biol-2022-0597

Open Life Sciences (May 2023)

The influence and mechanistic action of sperm DNA fragmentation index on the outcomes of assisted reproduction technology

Zhang Hui,
Zhu Fei-Yue,
He Xiao-Juan,
Tang Shi-Huan,
Long Ting,
Peng Lu,
Zhang Hong-Mei,
Zou Zong-Zhi,
Xiong Zhu,
Zhang Xian-Ping

Affiliations

Zhang Hui: Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
Zhu Fei-Yue: Department of Hematology, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
He Xiao-Juan: Department of Hematology, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
Tang Shi-Huan: Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
Long Ting: Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
Peng Lu: Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
Zhang Hong-Mei: Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China
Zou Zong-Zhi: Department of Nephropathy Endocrinology, The Second Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, 410000, China
Xiong Zhu: Department of Pediatric Orthopedics, Shenzhen Children’s Hospital of China Medical University, Guangdong, 518034, China
Zhang Xian-Ping: Department of Reproductive Medicine Center, Loudi Affiliated Hospital, Hengyang Medical School, University of South China, Loudi, 417000, China

DOI: https://doi.org/10.1515/biol-2022-0597
Journal volume & issue: Vol. 18, no. 1
pp. 308 – 22

Abstract

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We investigated the influence of DNA fragmentation index (DFI) on in vitro fertilization (IVF), embryo transfer (ET), and intracytoplasmic sperm injection (ICSI). We analyzed the semen parameters of 61 cycles in infertile couples undergoing IVF-ET and ICSI and determined DFI by sperm chromatin dispersion testing. Based on DFI, the patients were differentiated into a control group (DFI 0.05). Sperm DNA integrity is crucial for fertilization and the development of healthy offspring. ROS may increase the level of DFI by inducing apoptosis in sperm.

Published in Open Life Sciences

ISSN: 2391-5412 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Biology (General)
Website: http://www.degruyter.com/view/j/biol

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Abstract

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