Treatment of Glucantim™-Resistant Cutaneous Leishmaniasis Using Combination Therapy of Allopurinol and Trichloroacetic Acid (TCA) 50%; Report of Three Cases

Abstract

Background: Leishmaniasis is a disease transmitted by insects and in total, 88 countries are involved. If there is no remission with Glucantim as a choice of drug, other treatments such as cryotherapy and thermotherapy methods are used or other drugs such as allopurinol, pentamidine and amphotericin are prescribed in this disease. The use of trichloroacetic acid (TCA) 50% solution is another effective treatment. Case Report: We report three cases (two women and one man) of cutaneous leishmaniasis resistant to Glucantim treated with combination therapy of allopurinol and TCA 50%. Conclusion: According to the results, the use of combination therapy of allopurinol and TCA 50% could be used as one of the alternative treatments in Glucantim™-resistant cutaneous leishmaniasis.

Keywords

• Cutaneous leishmaniasis
• Glucantim
• Allopurinol
• Trichloroacetic acid (TCA) 50%