eFood (Jun 2023)

Myristicin: From its biological effects in traditional medicine in plants to preclinical studies and use as ecological remedy in plant protection

  • Karina Ramírez‐Alarcón,
  • Miquel Martorell,
  • Eda Sönmez Gürer,
  • Ismail Laher,
  • Hei‐Long Lam,
  • Ebtihal Abdalla M. Mohieldin,
  • Ali Mahoumd Muddathir,
  • Muhammad Akram,
  • Mehwish Iqbal,
  • Hamda Shafique,
  • Gerardo Leyva‐Gómez,
  • Shabnum Shaheen,
  • Manoj Kumar,
  • Javad Sharifi‐Rad,
  • Ryszard Amarowicz,
  • Monica Butnariu

DOI
https://doi.org/10.1002/efd2.90
Journal volume & issue
Vol. 4, no. 3
pp. n/a – n/a

Abstract

Read online

Abstract Myristicin is an allylbenzene and a major key constituent of many plant species, such as Myristica fragrans Houtt. (nutmeg), Foeniculum vulgare Mill. (fennel), and Petroselinum crispum (Mill.) Fuss (parsley). Their plant parts have been used in traditional medicine and as a flavoring seasoning for cooking but, and as biopesticides with natural compounds. Myristicin has been related with several biological effects, such as anticarcinogenic, anti‐inflammatory, antimicrobial, antioxidant, antidiabetic, analgesic, and hepatoprotective. The traditional uses include the treatment of complications related to gastrointestinal tract, respiratory system, and gynecological disorders. However, several studies have been reported contraindications associated to high dose consumption of myristicin. This review summarizes the biological activities of myristicin and myristicin‐rich plants, toxicological effects along with its bioavailability, and metabolism. In addition, their traditional uses and their role as ecological remedy in plants protection has been reviewed. Nutmeg is the myristicin‐rich plant with more pharmacological effects reported but also with most contraindication and toxically reports.

Keywords