Bridging the microscopic divide: a comprehensive overview of micro-crystallization and in vivo crystallography

Abstract

A series of events underscoring the significant advancements in micro-crystallization and in vivo crystallography were held during the 26th IUCr Congress in Melbourne, positioning microcrystallography as a pivotal field within structural biology. Through collaborative discussions and the sharing of innovative methodologies, these sessions outlined frontier approaches in macromolecular crystallography. This review provides an overview of this rapidly moving field in light of the rich dialogues and forward-thinking proposals explored during the congress workshop and microsymposium. These advances in microcrystallography shed light on the potential to reshape current research paradigms and enhance our comprehension of biological mechanisms at the molecular scale.

Keywords

• micro-crystallization
• in vivo crystallography
• structural biology
• macromolecular research
• in situ x-ray diffraction
• xfels
• microed