A systematic analysis of genetic interactions and their underlying biology in childhood cancer

Josephine T. Daub; Saman Amini; Denise J. E. Kersjes; Xiaotu Ma; Natalie Jäger; Jinghui Zhang; Stefan M. Pfister; Frank C. P. Holstege; Patrick Kemmeren

doi:10.1038/s42003-021-02647-4

Communications Biology (Oct 2021)

A systematic analysis of genetic interactions and their underlying biology in childhood cancer

Josephine T. Daub,
Saman Amini,
Denise J. E. Kersjes,
Xiaotu Ma,
Natalie Jäger,
Jinghui Zhang,
Stefan M. Pfister,
Frank C. P. Holstege,
Patrick Kemmeren

Affiliations

Josephine T. Daub: Princess Máxima Center for Pediatric Oncology
Saman Amini: Princess Máxima Center for Pediatric Oncology
Denise J. E. Kersjes: Princess Máxima Center for Pediatric Oncology
Xiaotu Ma: Computational Biology, St Jude Children’s Research Hospital
Natalie Jäger: Hopp Children´s Cancer Center Heidelberg (KiTZ) and Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)
Jinghui Zhang: Computational Biology, St Jude Children’s Research Hospital
Stefan M. Pfister: Hopp Children´s Cancer Center Heidelberg (KiTZ) and Division of Pediatric Neurooncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)
Frank C. P. Holstege: Princess Máxima Center for Pediatric Oncology
Patrick Kemmeren: Princess Máxima Center for Pediatric Oncology

DOI: https://doi.org/10.1038/s42003-021-02647-4
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 12

Abstract

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Josephine Daub, Saman Amini, et al. developed a genetic interaction map of childhood cancers by analyzing over 2,500 tumors from 23 types of childhood cancer. Their results provide a valuable resource for investigating the biological underpinnings of pediatric cancer.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal