Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of
<i>Vibrio cholerae</i>
O-Specific Polysaccharide-Specific Monoclonal Antibodies

Robert C. Kauffman; Oluwaseyi Adekunle; Hanyi Yu; Alice Cho; Lindsay E. Nyhoff; Meagan Kelly; Jason B. Harris; Taufiqur Rahman Bhuiyan; Firdausi Qadri; Stephen B. Calderwood; Richelle C. Charles; Edward T. Ryan; Jun Kong; Jens Wrammert

doi:10.1128/mBio.03679-20

mBio (Apr 2021)

Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of <i>Vibrio cholerae</i> O-Specific Polysaccharide-Specific Monoclonal Antibodies

Robert C. Kauffman,
Oluwaseyi Adekunle,
Hanyi Yu,
Alice Cho,
Lindsay E. Nyhoff,
Meagan Kelly,
Jason B. Harris,
Taufiqur Rahman Bhuiyan,
Firdausi Qadri,
Stephen B. Calderwood,
Richelle C. Charles,
Edward T. Ryan,
Jun Kong,
Jens Wrammert

Affiliations

Robert C. Kauffman: Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Oluwaseyi Adekunle: Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Hanyi Yu: Department of Computer Science, Emory University, Atlanta, Georgia, USA
Alice Cho: Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Lindsay E. Nyhoff: Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Meagan Kelly: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Jason B. Harris: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Taufiqur Rahman Bhuiyan: Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Firdausi Qadri: Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Stephen B. Calderwood: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Richelle C. Charles: ORCiD; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Edward T. Ryan: Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
Jun Kong: Department of Computer Science, Emory University, Atlanta, Georgia, USA
Jens Wrammert: ORCiD; Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

DOI: https://doi.org/10.1128/mBio.03679-20
Journal volume & issue: Vol. 12, no. 2

Abstract

Read online

Immunity to the severe diarrheal disease cholera is largely mediated by lipopolysaccharide (LPS)-specific antibodies. However, the properties and protective mechanism of functionally relevant antibodies have not been well defined.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal