Acquired von Willebrand syndrome in a patient with monoclonal gammopathy of unknown significance: A case report

Abstract

Abstract Monoclonal gammopathy of uncertain significance associated acquired von Willebrand syndrome is a serious bleeding condition driven by immunological clearance of von Willebrand factor and has limited treatment options. We present a patient who achieved durable remission through eradication of the monoclonal paraprotein with clonal directed therapy with bortezomib.

Keywords

• acquired von Willebrand disease
• bortezomib
• IVIG
• MGUS
• MGUS‐associated acquired von Willebrand syndrome
• rituximab