Nature Communications (Jan 2019)
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
- Amandine Everard,
- Hubert Plovier,
- Marialetizia Rastelli,
- Matthias Van Hul,
- Alice de Wouters d’Oplinter,
- Lucie Geurts,
- Céline Druart,
- Sylvie Robine,
- Nathalie M. Delzenne,
- Giulio G. Muccioli,
- Willem M. de Vos,
- Serge Luquet,
- Nicolas Flamand,
- Vincenzo Di Marzo,
- Patrice D. Cani
Affiliations
- Amandine Everard
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Hubert Plovier
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Marialetizia Rastelli
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Matthias Van Hul
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Alice de Wouters d’Oplinter
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Lucie Geurts
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Céline Druart
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Sylvie Robine
- Institut Curie, CNRS
- Nathalie M. Delzenne
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- Giulio G. Muccioli
- Bioanalysis and Pharmacology of Bioactive Lipids Research Group, Louvain Drug Research Institute, UCLouvain, Université catholique de Louvain
- Willem M. de Vos
- Laboratory of Microbiology, Wageningen University
- Serge Luquet
- Université Paris Diderot, Sorbonne Paris Cité, BFA, UMR8251, CNRS
- Nicolas Flamand
- Quebec Heart and Lung Institute Research Centre, Université Laval
- Vincenzo Di Marzo
- Quebec Heart and Lung Institute Research Centre, Université Laval
- Patrice D. Cani
- Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life sciences and BIOtechnology (WELBIO), UCLouvain, Université catholique de Louvain
- DOI
- https://doi.org/10.1038/s41467-018-08051-7
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Obesity is associated with altered N-acylethanolamine levels (NAE). Here the authors show that deletion of the gene encoding N-acylphosphatidylethanolamine phospholipase D, a key enzyme for NAE synthesis, in intestinal cells of mice leads to the development of obesity and hepatic steatosis via a mechanism involving the gut-brain axis.
