Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L

Cuige Zhu; Mari Iwase; Ziqian Li; Faliang Wang; Annabel Quinet; Alessandro Vindigni; Jieya Shao

doi:10.1038/s41467-022-34310-9

Nature Communications (Nov 2022)

Profilin-1 regulates DNA replication forks in a context-dependent fashion by interacting with SNF2H and BOD1L

Cuige Zhu,
Mari Iwase,
Ziqian Li,
Faliang Wang,
Annabel Quinet,
Alessandro Vindigni,
Jieya Shao

Affiliations

Cuige Zhu: Divison of Oncology, Department of Medicine, Washington University School of Medicine
Mari Iwase: Divison of Oncology, Department of Medicine, Washington University School of Medicine
Ziqian Li: Divison of Oncology, Department of Medicine, Washington University School of Medicine
Faliang Wang: Divison of Oncology, Department of Medicine, Washington University School of Medicine
Annabel Quinet: Divison of Oncology, Department of Medicine, Washington University School of Medicine
Alessandro Vindigni: Divison of Oncology, Department of Medicine, Washington University School of Medicine
Jieya Shao: Divison of Oncology, Department of Medicine, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34310-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Subcellular localization plays an important yet underappreciated role in protein functions. Here the authors defined novel and context-dependent nuclear functions of the actin-binding factor profilin-1 in DNA replication fork dynamics and stability.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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