SYNTHESIS OF BENDAMUSTINE HYDROCHLORIDE IN FLOW MICROREACTOR

Abstract

The possibility and prospects of carrying out the chlorination step in the scheme for the synthesis of bendamustine hydrochloride were investigated. The advantages and prospects of the process in the flow microreactor are shown. The conditions for conducting the process in the flow microreactor under which the chlorination reaction proceeds with a lower content of by-products and a higher yield are chosen.

Keywords

• flow microreactor
• sulfochlorination
• bendamustine hydrochloride