Communications Biology (Apr 2023)
Proton boron capture therapy (PBCT) induces cell death and mitophagy in a heterotopic glioblastoma model
- Francesco Paolo Cammarata,
- Filippo Torrisi,
- Nunzio Vicario,
- Valentina Bravatà,
- Alessandro Stefano,
- Lucia Salvatorelli,
- Simona D’Aprile,
- Pierangela Giustetto,
- Giusi Irma Forte,
- Luigi Minafra,
- Marco Calvaruso,
- Selene Richiusa,
- Giuseppe Antonio Pablo Cirrone,
- Giada Petringa,
- Giuseppe Broggi,
- Sebastiano Cosentino,
- Fabrizio Scopelliti,
- Gaetano Magro,
- Danilo Porro,
- Massimo Libra,
- Massimo Ippolito,
- Giorgio Russo,
- Rosalba Parenti,
- Giacomo Cuttone
Affiliations
- Francesco Paolo Cammarata
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Filippo Torrisi
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Nunzio Vicario
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Valentina Bravatà
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Alessandro Stefano
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Lucia Salvatorelli
- Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele” Anatomic Pathology, University of Catania
- Simona D’Aprile
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Pierangela Giustetto
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Giusi Irma Forte
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Luigi Minafra
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Marco Calvaruso
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Selene Richiusa
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Giuseppe Antonio Pablo Cirrone
- National Institute for Nuclear Physics, Laboratori Nazionali del Sud
- Giada Petringa
- National Institute for Nuclear Physics, Laboratori Nazionali del Sud
- Giuseppe Broggi
- Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele” Anatomic Pathology, University of Catania
- Sebastiano Cosentino
- Nuclear Medicine Department, Cannizzaro Hospital
- Fabrizio Scopelliti
- Radiopharmacy Laboratory Nuclear Medicine Department, Cannizzaro Hospital
- Gaetano Magro
- Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele” Anatomic Pathology, University of Catania
- Danilo Porro
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Massimo Libra
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Massimo Ippolito
- Nuclear Medicine Department, Cannizzaro Hospital
- Giorgio Russo
- Institute of Molecular Bioimaging and Physiology, National Research Council
- Rosalba Parenti
- Department of Biomedical and Biotechnological Sciences, University of Catania
- Giacomo Cuttone
- National Institute for Nuclear Physics, Laboratori Nazionali del Sud
- DOI
- https://doi.org/10.1038/s42003-023-04770-w
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 12
Abstract
Proton boron capture therapy (PBCT) in a preclinical glioblastoma model exhibits increased therapeutic effectiveness with an increased cell death and mitophagy, supporting its use as a scalable strategy to treat glioblastoma.
