Investigation of the roles of TGFβ1, CUG2, TGFBI genes, and thiol-disulfide balance on prostate cancer and metastasis

Tepebaşı Muhammet Yusuf; Sancer Okan; Aslan Koşar Pınar; Koşar Alim; İlhan İlter

doi:10.1515/tjb-2022-0259

Türk Biyokimya Dergisi (Jun 2023)

Investigation of the roles of TGFβ1, CUG2, TGFBI genes, and thiol-disulfide balance on prostate cancer and metastasis

Tepebaşı Muhammet Yusuf,
Sancer Okan,
Aslan Koşar Pınar,
Koşar Alim,
İlhan İlter

Affiliations

Tepebaşı Muhammet Yusuf: Department of Medical Genetics, University of Süleyman Demirel, Isparta, Türkiye
Sancer Okan: Department of Medical Biology, University of Süleyman Demirel, Isparta, Türkiye
Aslan Koşar Pınar: Department of Medical Biology, University of Süleyman Demirel, Isparta, Türkiye
Koşar Alim: Department of Urology, University of Süleyman Demirel, Isparta, Türkiye
İlhan İlter: Department of Biochemistry, University of Süleyman Demirel, Isparta, Türkiye

DOI: https://doi.org/10.1515/tjb-2022-0259
Journal volume & issue: Vol. 48, no. 3
pp. 257 – 263

Abstract

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Transforming growth factor-beta (TGFβ1) is involved in tumorigenesis and metastasis. It provides this effect both by disrupting the thiol-disulfide balance and through the cancer-upregulated gene (CUG2) and transforming growth factor beta-induced (TGFBI) genes in the signaling pathway. In this study, the roles of TGFβ1 and related genes, as well as thiol-disulfide balance, in the formation of prostate cancer and metastasis were investigated.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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Abstract

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