Altered functional connectivity within the primary visual networks and neurotransmitter activity in male smokers: A group ICA study

Jieping Sun; Jinghan Dang; Mengzhe zhang; Xiaoyu Niu; Qiuying Tao; Yimeng Kang; Longyao Ma; Bohui Mei; Yarui Wei; Weijian Wang; Shaoqiang Han; Jingliang Cheng; Yong Zhang

Brain Research Bulletin (Nov 2024)

Altered functional connectivity within the primary visual networks and neurotransmitter activity in male smokers: A group ICA study

Jieping Sun,
Jinghan Dang,
Mengzhe zhang,
Xiaoyu Niu,
Qiuying Tao,
Yimeng Kang,
Longyao Ma,
Bohui Mei,
Yarui Wei,
Weijian Wang,
Shaoqiang Han,
Jingliang Cheng,
Yong Zhang

Affiliations

Jieping Sun: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Jinghan Dang: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Mengzhe zhang: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Xiaoyu Niu: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Qiuying Tao: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Yimeng Kang: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Longyao Ma: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Bohui Mei: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Yarui Wei: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Weijian Wang: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Shaoqiang Han: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China
Jingliang Cheng: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China; Correspondence to: Department of MRI, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, No. 50 Jianshe East Road, Zhengzhou, Henan Province 450052, China.
Yong Zhang: Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China; Correspondence to: Department of MRI, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, No. 50 Jianshe East Road, Zhengzhou, Henan Province 450052, China.

Journal volume & issue: Vol. 218
p. 111098

Abstract

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Smoking puts patients at high risk for cognitive and psychiatric disorders. The aim of this study was to explore the effects of nicotine use on primary visual network (PVN) and its association with neurotransmitters. A total of 59 tobacco use disorder (TUD) patients and 51 healthy controls (HC) participated in this study and underwent resting state functional magnetic resonance imaging scans. Functional connectivity (FC) within the network was explored using independent component analysis. In addition, the spatial correlations of PVN changes with neurotransmitters and their correlations with clinical characteristics of patients were evaluated using the JuSpace toolbox and SPSS. We found reduced FC within the PVN in patients with TUD compared with HC. In terms of relevant analysis, there is a spatial correlation between FC changes in the patient's PVN and a higher distribution of dopamine receptor and gamma-aminobutyric acid receptor. This study revealed changes in the FC and neurotransmitters of the PVN in patients with TUD, expanding the potential neural mechanisms underlying sensory perception and psychiatric disorders.

Published in Brain Research Bulletin

ISSN: 1873-2747 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.sciencedirect.com/journal/brain-research-bulletin

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