Fluid shear stress activates YAP1 to promote cancer cell motility

Hyun Jung Lee; Miguel F. Diaz; Katherine M. Price; Joyce A. Ozuna; Songlin Zhang; Eva M. Sevick-Muraca; John P. Hagan; Pamela L. Wenzel

doi:10.1038/ncomms14122

Nature Communications (Jan 2017)

Fluid shear stress activates YAP1 to promote cancer cell motility

Hyun Jung Lee,
Miguel F. Diaz,
Katherine M. Price,
Joyce A. Ozuna,
Songlin Zhang,
Eva M. Sevick-Muraca,
John P. Hagan,
Pamela L. Wenzel

Affiliations

Hyun Jung Lee: Department of Pediatric Surgery, Children’s Regenerative Medicine Program, University of Texas Health Science Center at Houston
Miguel F. Diaz: Department of Pediatric Surgery, Children’s Regenerative Medicine Program, University of Texas Health Science Center at Houston
Katherine M. Price: Department of BioSciences, Rice University
Joyce A. Ozuna: Department of BioSciences, Rice University
Songlin Zhang: Department of Pathology, The University of Texas Medical School
Eva M. Sevick-Muraca: Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
John P. Hagan: Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center at Houston
Pamela L. Wenzel: Department of Pediatric Surgery, Children’s Regenerative Medicine Program, University of Texas Health Science Center at Houston

DOI: https://doi.org/10.1038/ncomms14122
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Fluid frictional forces around cancer cells influence chemokine production and delivery of chemotherapeutic drugs but it is unclear if they directly impact tumour biology through biomechanical effects. Here, the authors show that wall shear stress stimulates cancer cell migration through a ROCK–LIMK–YAP axis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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