PML degradation fosters an immunosuppressive and pro-metastatic tumor microenvironment

Abstract

The tumor suppressive functions of promyelocytic leukemia (PML) have been attributed mainly to its inhibition of various malignant properties of tumor cells. Our recent work identifies a PML ubiquitination and degradation pathway, which regulates both cell and non-cell components of the tumor microenvironment, thereby potentiating immune evasion and metastasis.

Keywords

• cd73
• metastasis
• pml
• tumor immunity
• ubiquitination
• wdr4