Serological biomarkers in autoimmune GFAP astrocytopathy

Cong-Cong Fu; Cong-Cong Fu; Lu Huang; Lu Huang; Lu-Fen Xu; Lu-Fen Xu; Li-Hong Jiang; Li-Hong Jiang; Hui-Lu Li; Hui-Lu Li; Sha Liao; Sha Liao; Jiajia Yue; Jiajia Yue; Chun Lian; Chun Lian; Xin-Guang Yang; Xin-Guang Yang; Xin-Guang Yang; You-Ming Long; You-Ming Long

doi:10.3389/fimmu.2022.957361

Frontiers in Immunology (Aug 2022)

Serological biomarkers in autoimmune GFAP astrocytopathy

Cong-Cong Fu,
Cong-Cong Fu,
Lu Huang,
Lu Huang,
Lu-Fen Xu,
Lu-Fen Xu,
Li-Hong Jiang,
Li-Hong Jiang,
Hui-Lu Li,
Hui-Lu Li,
Sha Liao,
Sha Liao,
Jiajia Yue,
Jiajia Yue,
Chun Lian,
Chun Lian,
Xin-Guang Yang,
Xin-Guang Yang,
Xin-Guang Yang,
You-Ming Long,
You-Ming Long

Affiliations

Cong-Cong Fu: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Cong-Cong Fu: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Lu Huang: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Lu Huang: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Lu-Fen Xu: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Lu-Fen Xu: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Li-Hong Jiang: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Li-Hong Jiang: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Hui-Lu Li: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Hui-Lu Li: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Sha Liao: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Sha Liao: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Jiajia Yue: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Jiajia Yue: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Chun Lian: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Chun Lian: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Xin-Guang Yang: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Xin-Guang Yang: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China
Xin-Guang Yang: Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
You-Ming Long: Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
You-Ming Long: Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China

DOI: https://doi.org/10.3389/fimmu.2022.957361
Journal volume & issue: Vol. 13

Abstract

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Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a newly defined meningoencephalomyelitis. The pathogenesis of GFAP-A is not well understood. The present study measured the expression levels of 200 serological cytokines in GFAP-A patients, NMOSD patients and healthy controls (HCs). The correlations between serum cytokine levels and clinical information in GFAP-A patients were analyzed. A total of 147 serological proteins were differentially expressed in GFAP-A patients compared to HCs, and 33 of these proteins were not observed in NMOSD patients. Serum levels of EG-VEGF negatively correlated with GFAP antibody titers, MIP-3 alpha positively correlated with clinical severity in GFAP-A patients, and LIGHT positively correlated with WBC counts and protein levels in the CSF of GFAP-A patients. These results suggest that GFAP and AQP4 astrocytopathy share some common pathology related to TNF signaling. Serum MIP 3 alpha may be a biomarker to assess clinical severity and a potential target for therapy of autoimmune GFAP astrocytopathy.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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