Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1

Tatsuya Hagino; Takafumi Kato; Go Kasuya; Kan Kobayashi; Tsukasa Kusakizako; Shin Hamamoto; Tomoaki Sobajima; Yuichiro Fujiwara; Keitaro Yamashita; Hisashi Kawasaki; Andrés D. Maturana; Tomohiro Nishizawa; Osamu Nureki

doi:10.1038/s41467-022-30292-w

Nature Communications (May 2022)

Cryo-EM structures of thylakoid-located voltage-dependent chloride channel VCCN1

Tatsuya Hagino,
Takafumi Kato,
Go Kasuya,
Kan Kobayashi,
Tsukasa Kusakizako,
Shin Hamamoto,
Tomoaki Sobajima,
Yuichiro Fujiwara,
Keitaro Yamashita,
Hisashi Kawasaki,
Andrés D. Maturana,
Tomohiro Nishizawa,
Osamu Nureki

Affiliations

Tatsuya Hagino: Department of Biological Science, Graduate School of Science, The University of Tokyo
Takafumi Kato: Department of Biological Science, Graduate School of Science, The University of Tokyo
Go Kasuya: Division of Integrative Physiology, Department of Physiology, Jichi Medical University
Kan Kobayashi: Department of Biological Science, Graduate School of Science, The University of Tokyo
Tsukasa Kusakizako: Department of Biological Science, Graduate School of Science, The University of Tokyo
Shin Hamamoto: Agro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Tomoaki Sobajima: Department of Biochemistry, University of Oxford
Yuichiro Fujiwara: Molecular Physiology and Biophysics, Faculty of Medicine, Kagawa University
Keitaro Yamashita: Department of Biological Science, Graduate School of Science, The University of Tokyo
Hisashi Kawasaki: Agro-Biotechnology Research Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Andrés D. Maturana: Department of Applied Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University
Tomohiro Nishizawa: Department of Biological Science, Graduate School of Science, The University of Tokyo
Osamu Nureki: Department of Biological Science, Graduate School of Science, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-30292-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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VCCN1 is a plant homolog of bestrophin channels and tunes photoreaction as a voltage-gated anion channel at thylakoids. Here, authors report the cryo-EM structures and functional features of apple VCCN1, with insights into its activation mechanism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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