Frontiers in Cardiovascular Medicine (Jan 2022)
Prognostic Value of Coronary CT Angiography-Derived Fractional Flow Reserve in Non-obstructive Coronary Artery Disease: A Prospective Multicenter Observational Study
- Fan Zhou,
- Qian Chen,
- Xiao Luo,
- Wei Cao,
- Ziwen Li,
- Bo Zhang,
- U. Joseph Schoepf,
- Callum E. Gill,
- Lili Guo,
- Hong Gao,
- Qingyao Li,
- Yibing Shi,
- Tingting Tang,
- Xiaochen Liu,
- Honglin Wu,
- Dongqing Wang,
- Feng Xu,
- Dongsheng Jin,
- Sheng Huang,
- Haige Li,
- Changjie Pan,
- Hongmei Gu,
- Lixiang Xie,
- Ximing Wang,
- Jing Ye,
- Jianwei Jiang,
- Hanqing Zhao,
- Xiangming Fang,
- Yi Xu,
- Wei Xing,
- Xiaohu Li,
- Xindao Yin,
- Guang Ming Lu,
- Long Jiang Zhang
Affiliations
- Fan Zhou
- Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Qian Chen
- Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
- Xiao Luo
- Department of Radiology, People's Hospital of Maanshan, Maanshan, China
- Wei Cao
- Department of Radiology, The First People's Hospital of Xuzhou, Xuzhou, China
- Ziwen Li
- Department of Radiology, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang, China
- Bo Zhang
- Department of Radiology, Taizhou People's Hospital, Taizhou, China
- U. Joseph Schoepf
- Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States
- Callum E. Gill
- Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States
- Lili Guo
- Department of Medical Imaging, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, China
- Hong Gao
- Department of Medical Imaging, Qinhuai Medical Region of Jinling Hospital, Nanjing, China
- Qingyao Li
- 0Department of Radiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Yibing Shi
- 1Department of Diagnostic Radiology, Xuzhou Central Hospital, Xuzhou, China
- Tingting Tang
- 2Department of Diagnostic Radiology, Yancheng No.1 Hospital, Affiliated Hospital of Nantong University, Yancheng, China
- Xiaochen Liu
- 3Department of Medical Imaging, Hai'an City People's Hospital, Haian, China
- Honglin Wu
- 4Department of Radiology, The Affiliated Wujin Hospital of Jiangsu University, Changzhou, China
- Dongqing Wang
- 5Department of Medical Imaging, Affiliated Hospital of Jiangsu University, Zhenjiang, China
- Feng Xu
- 6Department of Medical Imaging, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China
- Dongsheng Jin
- 7Department of Radiology, Jiangsu Province Official Hospital, Jiangsu Jiankang Vocational College, Nanjing, China
- Sheng Huang
- 8Department of Radiology, The Second Affiliated Hospital of Nantong University, Nantong, China
- Haige Li
- 9Department of Medical Imaging, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
- Changjie Pan
- 0Department of Radiology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, China
- Hongmei Gu
- 1Medical Imaging Center, Affiliated Hospital of Nantong University, Nantong, China
- Lixiang Xie
- 2Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
- Ximing Wang
- 3Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China
- Jing Ye
- 4Radiology Department, Subei People's Hospital of Jiangsu Province, Yangzhou, China
- Jianwei Jiang
- 5Department of Medical Imaging, Affiliated Hospital of Jiangnan University, Wuxi, China
- Hanqing Zhao
- 6Department of Medical Imaging, The Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou, China
- Xiangming Fang
- 7Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China
- Yi Xu
- 8Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
- Wei Xing
- 9Department of Radiology, Third Affiliated Hospital of Soochow University, Soochow University, Changzhou, China
- Xiaohu Li
- 0Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Xindao Yin
- Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China
- Guang Ming Lu
- Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- Long Jiang Zhang
- Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
- DOI
- https://doi.org/10.3389/fcvm.2021.778010
- Journal volume & issue
-
Vol. 8
Abstract
Coronary artery disease (CAD) is a major contributor to morbidity and mortality worldwide. Myocardial ischemia may occur in patients with normal or non-obstructive CAD on invasive coronary angiography (ICA). The comprehensive evaluation of coronary CT angiography (CCTA) integrated with fractional flow reserve derived from CCTA (CT-FFR) to CAD may be essential to improve the outcomes of patients with non-obstructive CAD. China CT-FFR Study-2 (ChiCTR2000031410) is a large-scale prospective, observational study in 29 medical centers in China. The primary purpose is to uncover the relationship between the CCTA findings (including CT-FFR) and the outcome of patients with non-obstructive CAD. At least 10,000 patients with non-obstructive CAD but without previous revascularization will be enrolled. A 5-year follow-up will be performed. The primary endpoint is the occurrence of major adverse cardiovascular events (MACE), including all-cause mortality, non-fatal myocardial infarct, unplanned revascularization, and hospitalization for unstable angina. Clinical characteristics, laboratory and imaging examination results will be collected to analyze their prognostic value.
Keywords
- non-obstructive coronary artery disease
- coronary computed tomography angiography
- fractional flow reserve
- major adverse cardiovascular events
- coronary plaque assessment
