Frontiers in Psychiatry (May 2020)
State-Independent Microstructural White Matter Abnormalities in Major Depressive Disorder
- Qiangli Dong,
- Qiangli Dong,
- Jin Liu,
- Jin Liu,
- Lingli Zeng,
- Yiming Fan,
- Xiaowen Lu,
- Xiaowen Lu,
- Jinrong Sun,
- Jinrong Sun,
- Liang Zhang,
- Liang Zhang,
- Mi Wang,
- Mi Wang,
- Hua Guo,
- Futao Zhao,
- Danfeng Yan,
- Danfeng Yan,
- Haolun Li,
- Haolun Li,
- Weilong Guo,
- Weilong Guo,
- Yan Zhang,
- Yan Zhang,
- Bangshan Liu,
- Bangshan Liu,
- Dewen Hu,
- Lingjiang Li,
- Lingjiang Li
Affiliations
- Qiangli Dong
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Qiangli Dong
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Jin Liu
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Jin Liu
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Lingli Zeng
- College of Intelligence Science and Technology, National University of Defense Technology, Changsha, China
- Yiming Fan
- College of Intelligence Science and Technology, National University of Defense Technology, Changsha, China
- Xiaowen Lu
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Xiaowen Lu
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Jinrong Sun
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Jinrong Sun
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Liang Zhang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Liang Zhang
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Mi Wang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Mi Wang
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Hua Guo
- Department of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, China
- Futao Zhao
- Department of Psychiatry, Zhumadian Psychiatric Hospital, Zhumadian, China
- Danfeng Yan
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Danfeng Yan
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Haolun Li
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Haolun Li
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Weilong Guo
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Weilong Guo
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Yan Zhang
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Yan Zhang
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Bangshan Liu
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Bangshan Liu
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- Dewen Hu
- College of Intelligence Science and Technology, National University of Defense Technology, Changsha, China
- Lingjiang Li
- Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, China
- Lingjiang Li
- Mental Health Institute of Central South University, China National Clinical Research Center on Mental Disorders (Xiangya), China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China
- DOI
- https://doi.org/10.3389/fpsyt.2020.00431
- Journal volume & issue
-
Vol. 11
Abstract
BackgroundEven with continuous antidepressant treatment, residual symptoms and the risk of relapse can persist in remitted major depressive disorder (MDD) patients. Hence, having a clear recognition of the persistent abnormalities of the underlying neural substrate in MDD through a longitudinal investigation is of great importance.MethodsA total of 127 adult medication-free MDD patients with an acute depressive episode and 118 matched healthy controls (HCs) underwent diffusion tensor imaging. Over a 6-month treatment course, 62 remitted patients underwent a second scan. Remission was defined as a 24-item Hamilton Depression Rating Scale (HAMD24) score ≤7 for at least two weeks. Diffusion tensor imaging was performed with a 3.0 T scanner. Differences in whole-brain fractional anisotropy (FA) between MDD patients and HCs were assessed by an independent t-test using gender, age, and education as covariates.ResultsSignificant FA reductions in the left insula, left middle occipital gyrus, right thalamus, left pallidum and left precuneus were observed in current MDD (cMDD) patients compared with HCs. Moreover, significant FA reductions in the left insula were observed in remitted (rMDD) patients compared to HCs. However, no significant differences in FA values were found when comparing cMDD and rMDD patients.ConclusionsThe abnormalities in the insula showed state-independent characteristics, while the abnormalities in the middle occipital gyrus, thalamus, pallidum and precuneus seemed to be state-dependent impairments in MDD patients.
Keywords
- major depressive disorder
- diffusion tensor imaging
- white matter microstructure
- fractional anisotropy
- state-independent
