Nature Communications (Nov 2019)
Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
- Jongha Lee,
- Hye Rim Cho,
- Gi Doo Cha,
- Hyunseon Seo,
- Seunghyun Lee,
- Chul-Kee Park,
- Jin Wook Kim,
- Shutao Qiao,
- Liu Wang,
- Dayoung Kang,
- Taegyu Kang,
- Tomotsugu Ichikawa,
- Jonghoon Kim,
- Hakyong Lee,
- Woongchan Lee,
- Sanghoek Kim,
- Soon-Tae Lee,
- Nanshu Lu,
- Taeghwan Hyeon,
- Seung Hong Choi,
- Dae-Hyeong Kim
Affiliations
- Jongha Lee
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Hye Rim Cho
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Gi Doo Cha
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Hyunseon Seo
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Seunghyun Lee
- Department of Radiology, Seoul National University College of Medicine
- Chul-Kee Park
- Department of Neurosurgery, Seoul National University College of Medicine
- Jin Wook Kim
- Department of Neurosurgery, Seoul National University College of Medicine
- Shutao Qiao
- Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin
- Liu Wang
- Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin
- Dayoung Kang
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Taegyu Kang
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Tomotsugu Ichikawa
- Department of Neurological surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
- Jonghoon Kim
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Hakyong Lee
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Woongchan Lee
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Sanghoek Kim
- Department of Electronics and Radio Engineering, Kyung Hee University
- Soon-Tae Lee
- Department of Neurology, Seoul National University College of Medicine
- Nanshu Lu
- Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin
- Taeghwan Hyeon
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Seung Hong Choi
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- Dae-Hyeong Kim
- Center for Nanoparticle Research, Institute for Basic Science (IBS)
- DOI
- https://doi.org/10.1038/s41467-019-13198-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 9
Abstract
There is a need to further improve the efficacy of biodegradable wafers used in surgically treated brain tumors. Here, the authors report a flexible, biodegradable wireless device capable of adhesion to surgical site for optimal drug delivery upon mild-thermic actuation and report therapeutic efficacy in mouse and canine tumor models.
