A case of COVID-19-associated rhino-orbito-cerebral mucormycosis caused by Apophysomyces variabilis with a review of the literature

Mahzad Erami; Mahzad Erami; Hossein Mirhendi; Hossein Mirhendi; Mansooreh Momen-Heravi; Seyed Jamal Hashemi Hezaveh; Amir Hossein Ahsaniarani; Seddighe Sadat Sabet; Shima Aboutalebian; Shima Aboutalebian

doi:10.3389/fcimb.2022.898477

Frontiers in Cellular and Infection Microbiology (Oct 2022)

A case of COVID-19-associated rhino-orbito-cerebral mucormycosis caused by Apophysomyces variabilis with a review of the literature

Mahzad Erami,
Mahzad Erami,
Hossein Mirhendi,
Hossein Mirhendi,
Mansooreh Momen-Heravi,
Seyed Jamal Hashemi Hezaveh,
Amir Hossein Ahsaniarani,
Seddighe Sadat Sabet,
Shima Aboutalebian,
Shima Aboutalebian

Affiliations

Mahzad Erami: Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mahzad Erami: Infectious Disease Research Center, Kashan University of Medical Sciences, Kashan, Iran
Hossein Mirhendi: Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Hossein Mirhendi: Mycology Reference Laboratory, Research Core Facilities Laboratory, Isfahan University of Medical Sciences, Isfahan, Iran
Mansooreh Momen-Heravi: Infectious Disease Research Center, Kashan University of Medical Sciences, Kashan, Iran
Seyed Jamal Hashemi Hezaveh: Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Amir Hossein Ahsaniarani: Department Otorhinolaryngology, School of Medicine, Matini Hospital, Kashan University of Medical Sciences, Kashan, Iran
Seddighe Sadat Sabet: Department of Pharmaceutical, Kashan University of Medical Sciences, Kashan, Iran
Shima Aboutalebian: Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Shima Aboutalebian: Mycology Reference Laboratory, Research Core Facilities Laboratory, Isfahan University of Medical Sciences, Isfahan, Iran

DOI: https://doi.org/10.3389/fcimb.2022.898477
Journal volume & issue: Vol. 12

Abstract

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A fatal case of COVID-19-associated mucormycosis (CAM) affected a 40-year-old woman who was initially admitted to our hospital due to a SARS-CoV-2 infection. Her clinical condition worsened, and she finally died because of respiratory failure, hemodynamic instability, and mucormycosis with invasion into the orbit and probably the brain. According to DNA sequence analysis of the fungus isolated from the patient, Apophysomyces variabilis was involved. This is the first published case of CAM and the third case of mucormycosis due to this mold.

Published in Frontiers in Cellular and Infection Microbiology

ISSN: 2235-2988 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/Cellular-and-Infection-Microbiology

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