Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

Adam Institoris; Milène Vandal; Govind Peringod; Christy Catalano; Cam Ha Tran; Xinzhu Yu; Frank Visser; Cheryl Breiteneder; Leonardo Molina; Baljit S. Khakh; Minh Dang Nguyen; Roger J. Thompson; Grant R. Gordon

doi:10.1038/s41467-022-35383-2

Nature Communications (Dec 2022)

Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

Adam Institoris,
Milène Vandal,
Govind Peringod,
Christy Catalano,
Cam Ha Tran,
Xinzhu Yu,
Frank Visser,
Cheryl Breiteneder,
Leonardo Molina,
Baljit S. Khakh,
Minh Dang Nguyen,
Roger J. Thompson,
Grant R. Gordon

Affiliations

Adam Institoris: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Milène Vandal: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Govind Peringod: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Christy Catalano: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Cam Ha Tran: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Xinzhu Yu: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
Frank Visser: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Cheryl Breiteneder: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary
Leonardo Molina: Hotchkiss Brain Institute, Department of Clinical Neuroscience, Cumming School of Medicine, University of Calgary
Baljit S. Khakh: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
Minh Dang Nguyen: Hotchkiss Brain Institute, Department of Clinical Neuroscience, Cumming School of Medicine, University of Calgary
Roger J. Thompson: Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary
Grant R. Gordon: Hotchkiss Brain Institute, Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary

DOI: https://doi.org/10.1038/s41467-022-35383-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Neuronal activity increases local cerebral blood flow (CBF) to satisfy metabolic demand, yet the role of astrocytes in this phenomenon is controversial. Here, the authors show that astrocytes amplify CBF only when neuronal activity is sustained.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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