A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance

Emily J. Furlong; Alvin W. Lo; Fabian Kurth; Lakshmanane Premkumar; Makrina Totsika; Maud E. S. Achard; Maria A. Halili; Begoña Heras; Andrew E. Whitten; Hassanul G. Choudhury; Mark A. Schembri; Jennifer L. Martin

doi:10.1038/ncomms16065

Nature Communications (Jul 2017)

A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance

Emily J. Furlong,
Alvin W. Lo,
Fabian Kurth,
Lakshmanane Premkumar,
Makrina Totsika,
Maud E. S. Achard,
Maria A. Halili,
Begoña Heras,
Andrew E. Whitten,
Hassanul G. Choudhury,
Mark A. Schembri,
Jennifer L. Martin

Affiliations

Emily J. Furlong: Institute for Molecular Bioscience, University of Queensland
Alvin W. Lo: School of Chemistry and Molecular Biosciences, University of Queensland
Fabian Kurth: Institute for Molecular Bioscience, University of Queensland
Lakshmanane Premkumar: Institute for Molecular Bioscience, University of Queensland
Makrina Totsika: School of Chemistry and Molecular Biosciences, University of Queensland
Maud E. S. Achard: School of Chemistry and Molecular Biosciences, University of Queensland
Maria A. Halili: Institute for Molecular Bioscience, University of Queensland
Begoña Heras: La Trobe Institute for Molecular Science, La Trobe University
Andrew E. Whitten: Institute for Molecular Bioscience, University of Queensland
Hassanul G. Choudhury: Institute for Molecular Bioscience, University of Queensland
Mark A. Schembri: School of Chemistry and Molecular Biosciences, University of Queensland
Jennifer L. Martin: Institute for Molecular Bioscience, University of Queensland

DOI: https://doi.org/10.1038/ncomms16065
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Bacterial disulfide isomerases shuffle incorrect disulfide bonds. Here, the authors structurally characterize the disulfide isomerase ScsC fromProteus mirabilisand identify a functionally important shape-shifting motif that allows ScsC to adopt a diverse range of conformations and enable swarming in the presence of copper stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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