Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

Samantha Stanley; Kamala Vanarsa; Samar Soliman; Deena Habazi; Claudia Pedroza; Gabriel Gidley; Ting Zhang; Shree Mohan; Evan Der; Hemant Suryawanshi; Thomas Tuschl; Jill Buyon; Chaim Putterman; Chi Chiu Mok; Michelle Petri; Ramesh Saxena; Chandra Mohan

doi:10.1038/s41467-020-15986-3

Nature Communications (May 2020)

Comprehensive aptamer-based screening identifies a spectrum of urinary biomarkers of lupus nephritis across ethnicities

Samantha Stanley,
Kamala Vanarsa,
Samar Soliman,
Deena Habazi,
Claudia Pedroza,
Gabriel Gidley,
Ting Zhang,
Shree Mohan,
Evan Der,
Hemant Suryawanshi,
Thomas Tuschl,
Jill Buyon,
Chaim Putterman,
Chi Chiu Mok,
Michelle Petri,
Ramesh Saxena,
Chandra Mohan

Affiliations

Samantha Stanley: Department Biomedical Engineering, University of Houston
Kamala Vanarsa: Department Biomedical Engineering, University of Houston
Samar Soliman: Department Biomedical Engineering, University of Houston
Deena Habazi: Department Biomedical Engineering, University of Houston
Claudia Pedroza: Center for Clinical Research and Evidence-Based Medicine, University of Texas Health Science Center at Houston
Gabriel Gidley: Department Biomedical Engineering, University of Houston
Ting Zhang: Department Biomedical Engineering, University of Houston
Shree Mohan: Department Biomedical Engineering, University of Houston
Evan Der: Department of Rheumatology, Albert Einstein College of Medicine
Hemant Suryawanshi: Department of Molecular Biology, Rockefeller University
Thomas Tuschl: Department of Molecular Biology, Rockefeller University
Jill Buyon: Department of Rheumatology, New York University
Chaim Putterman: Department of Rheumatology, Albert Einstein College of Medicine
Chi Chiu Mok: Department of Medicine, Tuen Mun Hospital
Michelle Petri: Division of Rheumatology, Johns Hopkins University School of Medicine
Ramesh Saxena: University Hospital Kidney & Liver Clinic, University of Texas Southwestern Medical Center
Chandra Mohan: Department Biomedical Engineering, University of Houston

DOI: https://doi.org/10.1038/s41467-020-15986-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Developing noninvasive diagnostic biomarkers for lupus nephritis (LN) diagnosis is an important clinical goal. Here the authors identify urinary proteins correlated with active LN and disease severity, which differ across ethnicities but collectively outperform the current clinical method.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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