Quantitative Proteomic Analysis of Zearalenone Exposure on Uterine Development in Weaned Gilts

Xinglin Liu; Zengchun Wang; Yanping Jiang; Libo Huang; Xuejun Yuan; Yang Li; Ning Jiao; Weiren Yang; Shuzhen Jiang

doi:10.3390/toxins14100692

Toxins (Oct 2022)

Quantitative Proteomic Analysis of Zearalenone Exposure on Uterine Development in Weaned Gilts

Xinglin Liu,
Zengchun Wang,
Yanping Jiang,
Libo Huang,
Xuejun Yuan,
Yang Li,
Ning Jiao,
Weiren Yang,
Shuzhen Jiang

Affiliations

Xinglin Liu: Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China
Zengchun Wang: Shandong Muge Animal Husbandry Equipment Co., Ltd., Yucheng 251200, China
Yanping Jiang: Zhongcheng Feed Technology Co., Ltd., Feicheng 271600, China
Libo Huang: Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China
Xuejun Yuan: Department of Life Sciences, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China
Yang Li: Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China
Ning Jiao: Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China
Weiren Yang: Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China
Shuzhen Jiang: Colloge of Animal Sciences and Veterinary Medicine, Shandong Agricultural University, No. 61 Daizong Street, Tai’an 271018, China

DOI: https://doi.org/10.3390/toxins14100692
Journal volume & issue: Vol. 14, no. 10
p. 692

Abstract

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The aim of this study was to explore the effect of zearalenone (ZEA) exposure on uterine development in weaned gilts by quantitative proteome analysis with tandem mass spectrometry tags (TMT). A total of 16 healthy weaned gilts were randomly divided into control (basal diet) and ZEA3.0 treatments groups (basal diet supplemented with 3.0 mg/kg ZEA). Results showed that vulva size and uterine development index were increased (p p p p p p < 0.01). This study sheds new light on the molecular mechanism of ZEA in the uterine development of gilts.

Published in Toxins

ISSN: 2072-6651 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/toxins/

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Abstract

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