Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

Fei Ye; Fanli Yang; Ruijie Yu; Xi Lin; Jianxun Qi; Zhujun Chen; Yu Cao; Yuquan Wei; George F. Gao; Guangwen Lu

doi:10.1038/s41467-018-03625-x

Nature Communications (Mar 2018)

Molecular basis of binding between the global post-transcriptional regulator CsrA and the T3SS chaperone CesT

Fei Ye,
Fanli Yang,
Ruijie Yu,
Xi Lin,
Jianxun Qi,
Zhujun Chen,
Yu Cao,
Yuquan Wei,
George F. Gao,
Guangwen Lu

Affiliations

Fei Ye: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Fanli Yang: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Ruijie Yu: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Xi Lin: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Jianxun Qi: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Zhujun Chen: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Yu Cao: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Yuquan Wei: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
George F. Gao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences
Guangwen Lu: West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy

DOI: https://doi.org/10.1038/s41467-018-03625-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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CesT is a type III secretion system chaperone that interacts with the post-transcriptional regulator CsrA, which is important for the modulation of post-attachment signaling in enteropathogenic and enterohemorrhagic Escherichia coli. Here the authors present the structure of the CsrA/CesT complex and propose a mechanism for CsrA-modulation by CesT.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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