Nature Communications (Jul 2022)
RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R
- Jana H. Badrani,
- Allyssa N. Strohm,
- Lee Lacasa,
- Blake Civello,
- Kellen Cavagnero,
- Yung-An Haung,
- Michael Amadeo,
- Luay H. Naji,
- Sean J. Lund,
- Anthea Leng,
- Hyojoung Kim,
- Rachel E. Baum,
- Naseem Khorram,
- Monalisa Mondal,
- Grégory Seumois,
- Julie Pilotte,
- Peter W. Vanderklish,
- Heather M. McGee,
- Taylor A. Doherty
Affiliations
- Jana H. Badrani
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Allyssa N. Strohm
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Lee Lacasa
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Blake Civello
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Kellen Cavagnero
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Yung-An Haung
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Michael Amadeo
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Luay H. Naji
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Sean J. Lund
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Anthea Leng
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Hyojoung Kim
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Rachel E. Baum
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Naseem Khorram
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Monalisa Mondal
- La Jolla Institute
- Grégory Seumois
- La Jolla Institute
- Julie Pilotte
- The Scripps Research Institute
- Peter W. Vanderklish
- The Scripps Research Institute
- Heather M. McGee
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- Taylor A. Doherty
- Divison of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-022-32176-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The function of RNA binding proteins within innate lymphoid cells (ILC) has been partially characterised. Here the authors show that RBM3 functions to limit the type 2 immunity promoting activity of ILC2 partially through cysteinyl leukotriene 1 receptor.
