Communications Biology (Feb 2022)
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux
- Idit Dotan,
- Jiaqi Yang,
- Jiro Ikeda,
- Ziv Roth,
- Evan Pollock-Tahiri,
- Harsh Desai,
- Tharini Sivasubramaniyam,
- Sonia Rehal,
- Josh Rapps,
- Yu Zhe Li,
- Helen Le,
- Gedaliah Farber,
- Edouard Alchami,
- Changting Xiao,
- Saraf Karim,
- Marcela Gronda,
- Michael F. Saikali,
- Amit Tirosh,
- Kay-Uwe Wagner,
- Jacques Genest,
- Aaron D. Schimmer,
- Vikas Gupta,
- Mark D. Minden,
- Carolyn L. Cummins,
- Gary F. Lewis,
- Clinton Robbins,
- Jenny Jongstra-Bilen,
- Myron Cybulsky,
- Minna Woo
Affiliations
- Idit Dotan
- Toronto General Hospital Research Institute, University Health Network
- Jiaqi Yang
- Toronto General Hospital Research Institute, University Health Network
- Jiro Ikeda
- Toronto General Hospital Research Institute, University Health Network
- Ziv Roth
- Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children
- Evan Pollock-Tahiri
- Toronto General Hospital Research Institute, University Health Network
- Harsh Desai
- Toronto General Hospital Research Institute, University Health Network
- Tharini Sivasubramaniyam
- Toronto General Hospital Research Institute, University Health Network
- Sonia Rehal
- Toronto General Hospital Research Institute, University Health Network
- Josh Rapps
- Toronto General Hospital Research Institute, University Health Network
- Yu Zhe Li
- Toronto General Hospital Research Institute, University Health Network
- Helen Le
- Toronto General Hospital Research Institute, University Health Network
- Gedaliah Farber
- Toronto General Hospital Research Institute, University Health Network
- Edouard Alchami
- Department of Immunology, University of Toronto
- Changting Xiao
- Toronto General Hospital Research Institute, University Health Network
- Saraf Karim
- Toronto General Hospital Research Institute, University Health Network
- Marcela Gronda
- Princess Margaret Cancer Centre, University Health Network
- Michael F. Saikali
- Department of Pharmaceutical Sciences, University of Toronto
- Amit Tirosh
- Endocrine Cancer Genomics Center, Sheba Medical Center
- Kay-Uwe Wagner
- Department of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute
- Jacques Genest
- Research Institute of the McGill University Health Centre, Royal Victoria Hospital
- Aaron D. Schimmer
- Princess Margaret Cancer Centre, University Health Network
- Vikas Gupta
- Princess Margaret Cancer Centre, University Health Network
- Mark D. Minden
- Princess Margaret Cancer Centre, University Health Network
- Carolyn L. Cummins
- Department of Pharmaceutical Sciences, University of Toronto
- Gary F. Lewis
- Toronto General Hospital Research Institute, University Health Network
- Clinton Robbins
- Toronto General Hospital Research Institute, University Health Network
- Jenny Jongstra-Bilen
- Toronto General Hospital Research Institute, University Health Network
- Myron Cybulsky
- Toronto General Hospital Research Institute, University Health Network
- Minna Woo
- Toronto General Hospital Research Institute, University Health Network
- DOI
- https://doi.org/10.1038/s42003-022-03078-5
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Loss of myeloid JAK2 promotes atherosclerosis in an ApoE knockout mouse model. This is associated with decreased cholesterol efflux from bone-marrow-derived macrophages.
