Stereoselective Synthesis of the C19–C39 Fragment of Bastimolide A

Abstract

This paper describes the synthesis of the C19–C39 fragment of the antimalarial natural product bastimolide A via addition of a functionalized C19–C26 alkyne fragment to a C27–C39 aldehyde fragment. Opening of a terminal epoxide and Noyori asymmetric reduction were used as key steps in the synthesis.

Keywords

• bastimolide a
• antimalarial activity
• stereoselective synthesis
• epoxide opening
• noyori asymmetric reduction