Artemis and its role in cancer

Armen Parsyan; Vasudeva Bhat; Harjot Athwal; Emily A. Goebel; Alison L Allan

Translational Oncology (Jan 2025)

Artemis and its role in cancer

Armen Parsyan,
Vasudeva Bhat,
Harjot Athwal,
Emily A. Goebel,
Alison L Allan

Affiliations

Armen Parsyan: Department of Anatomy and Cell Biology, Western University, London, ON, N6A 3K7, Canada; Verspeeten Family Cancer Centre, London Health Sciences Centre, London, ON, N6A 5W9, Canada; Department of Oncology, Western University, London, ON, N6A 3K7, Canada; Department of Surgery, St Joseph's Health Care and London Health Sciences Centre, Western University, London, ON, N6A 4V2, Canada; Corresponding author at: 268 Grosvenor St, D1-204, London ON N6A 4V2.
Vasudeva Bhat: Department of Anatomy and Cell Biology, Western University, London, ON, N6A 3K7, Canada; Verspeeten Family Cancer Centre, London Health Sciences Centre, London, ON, N6A 5W9, Canada
Harjot Athwal: Department of Anatomy and Cell Biology, Western University, London, ON, N6A 3K7, Canada
Emily A. Goebel: Department of Pathology and Laboratory Medicine, London Health Sciences Centre and Western University, London, ON, N6A 5A5, Canada
Alison L Allan: Department of Anatomy and Cell Biology, Western University, London, ON, N6A 3K7, Canada; Verspeeten Family Cancer Centre, London Health Sciences Centre, London, ON, N6A 5W9, Canada; Department of Oncology, Western University, London, ON, N6A 3K7, Canada

Journal volume & issue: Vol. 51
p. 102165

Abstract

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Artemis is a key nuclease involved in the non-homologous end joining repair pathway upon DNA double-stranded breaks and during V(D)J recombination. It participates in various cellular processes and cooperates with various proteins involved in tumorigenesis. Its hereditary mutations lead to several pathological conditions, such as severe combined immunodeficiency with radiation sensitivity. Recent studies suggest that Artemis deregulation plays an important role in cancer and is associated with poorer oncologic outcomes and resistance to treatment including radiotherapy, chemotherapy and targeted therapeutics. Artemis emerges as an attractive candidate for cancer prognosis and treatment. Its role in modulating sensitivity to ionizing radiation and DNA-damaging agents makes it an appealing target for drug development. Various existing drugs and novel compounds have been described to inhibit Artemis activity. This review synthesizes the up-to-date information regarding Artemis function, its role in different malignancies and its clinical utility as a potential biomarker and therapeutic target in Oncology.

Published in Translational Oncology

ISSN: 1944-7124 (Print); 1936-5233 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/translational-oncology/

About the journal

Abstract

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