Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia

Li Qi; Cheng Yujing; Chen Wanlu; Wang Ying; Dai Run; Yang Xin

doi:10.1515/med-2023-0782

Open Medicine (Aug 2023)

Pan-cancer analysis of the PDE4DIP gene with potential prognostic and immunotherapeutic values in multiple cancers including acute myeloid leukemia

Li Qi,
Cheng Yujing,
Chen Wanlu,
Wang Ying,
Dai Run,
Yang Xin

Affiliations

Li Qi: Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032Kunming, Yunnan, China
Cheng Yujing: Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032Kunming, Yunnan, China
Chen Wanlu: Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032Kunming, Yunnan, China
Wang Ying: Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032Kunming, Yunnan, China
Dai Run: Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032Kunming, Yunnan, China
Yang Xin: Department of Blood Transfusion, The First People’s Hospital of Yunnan Province – The Affiliated Hospital of Kunming University of Science and Technology, 650032Kunming, Yunnan, China

DOI: https://doi.org/10.1515/med-2023-0782
Journal volume & issue: Vol. 18, no. 1
pp. 3791 – 802

Abstract

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Phosphodiesterase 4D interacting protein (PDE4DIP) interacts with cAMP-specific phosphodiesterase 4D and its abnormal expression promotes the development of hematological malignancies, breast cancer, and pineal cell carcinoma. However, there is currently no systematic pan-cancer analysis of the association between PDE4DIP and various cancers. Thus, this study aimed to elucidate the potential functions of PDE4DIP in various cancers. Based on the multiple public databases and online websites, we conducted comprehensive analyses for PDE4DIP in various cancers, including differential expression, prognosis, genetic variation, DNA methylation, and immunity. We thoroughly analyzed the specific role of PDE4DIP in acute myeloid leukemia (LAML). The results indicated that there were differences in PDE4DIP expression in cancers, and in kidney chromophobe, LAML, pheochromocytoma and paraganglioma, thymoma, and uveal melanoma, PDE4DIP had potential prognostic value. PDE4DIP expression was also correlated with genetic variation, DNA methylation, immune cell infiltration, and immune-related genes in cancers. Functional enrichment analysis showed that PDE4DIP was mainly related to immune-related pathways in cancers, and in LAML, PDE4DIP was mainly related to immunoglobulin complexes, T-cell receptor complexes, and immune response regulatory signaling pathways. Our study systematically revealed for the first time the potential prognostic and immunotherapeutic value of PDE4DIP in various cancers, including LAML.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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Abstract

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