An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate

Chunfeng Chen; Chunlei Lv; Jianfeng Liang; Jianqing Jin; Lijun Wang; Chunlei Wu; Runpu Shen

doi:10.3390/molecules22081295

Molecules (Aug 2017)

An Efficient Synthesis of Spiro[indoline-3,9′-xanthene]trione Derivatives Catalyzed by Magnesium Perchlorate

Chunfeng Chen,
Chunlei Lv,
Jianfeng Liang,
Jianqing Jin,
Lijun Wang,
Chunlei Wu,
Runpu Shen

Affiliations

Chunfeng Chen: Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, Zhejiang, China
Chunlei Lv: Zhejiang Medicine Co., Ltd., Shaoxing 312000, Zhejiang, China
Jianfeng Liang: Zhejiang Medicine Co., Ltd., Shaoxing 312000, Zhejiang, China
Jianqing Jin: Zhejiang Medicine Co., Ltd., Shaoxing 312000, Zhejiang, China
Lijun Wang: Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, Zhejiang, China
Chunlei Wu: Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, Zhejiang, China
Runpu Shen: Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, Zhejiang, China

DOI: https://doi.org/10.3390/molecules22081295
Journal volume & issue: Vol. 22, no. 8
p. 1295

Abstract

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A simple and efficient method for the synthesis of spiro[indoline-3,9′-xanthene]trione derivatives by means of condensation between isatins and 1,3-cyclohexanedione in the presence of a catalytic amount of magnesium perchlorate at 80 °C in 50% aqueous ethanol medium has been described. Notably, the present method offers desirable advantages of good yields, simplicity of workup procedure, easy purification, and reduced reaction times.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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