Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Jinyu Wang; Weibo Zhao; Haixiao Chen; An Qin; Peizhi Zhu

doi:10.1186/s11671-017-2324-1

Nanoscale Research Letters (Oct 2017)

Anti-tumor Study of Chondroitin Sulfate-Methotrexate Nanogels

Jinyu Wang,
Weibo Zhao,
Haixiao Chen,
An Qin,
Peizhi Zhu

Affiliations

Jinyu Wang: College of Chemistry and Chemical Engineering, Yangzhou University
Weibo Zhao: Orthopaedic Department, Taizhou Hospital, Wenzhou Medical University
Haixiao Chen: Orthopaedic Department, Taizhou Hospital, Wenzhou Medical University
An Qin: Department of Orthopedic Surgery, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Peizhi Zhu: College of Chemistry and Chemical Engineering, Yangzhou University

DOI: https://doi.org/10.1186/s11671-017-2324-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Abstract Self-assembly nanogels (NGs) were formed by bioconjugating methotrexate (MTX) with chondroitin sulfate (CS). MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS. Vivo experiments revealed that MTX-CS NGs showed less toxicity than MTX. MTX-CS NGs can improve the anti-tumor effect while reducing the side effects of MTX. Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.

Published in Nanoscale Research Letters

ISSN: 1931-7573 (Print); 1556-276X (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.springer.com/journal/11671

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Abstract

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