Nature Communications (May 2018)
Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
- Ben Krause-Kyora,
- Marcel Nutsua,
- Lisa Boehme,
- Federica Pierini,
- Dorthe Dangvard Pedersen,
- Sabin-Christin Kornell,
- Dmitriy Drichel,
- Marion Bonazzi,
- Lena Möbus,
- Peter Tarp,
- Julian Susat,
- Esther Bosse,
- Beatrix Willburger,
- Alexander H. Schmidt,
- Jürgen Sauter,
- Andre Franke,
- Michael Wittig,
- Amke Caliebe,
- Michael Nothnagel,
- Stefan Schreiber,
- Jesper L. Boldsen,
- Tobias L. Lenz,
- Almut Nebel
Affiliations
- Ben Krause-Kyora
- Institute of Clinical Molecular Biology, Kiel University
- Marcel Nutsua
- Institute of Clinical Molecular Biology, Kiel University
- Lisa Boehme
- Institute of Clinical Molecular Biology, Kiel University
- Federica Pierini
- Department of Evolutionary Ecology, Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology
- Dorthe Dangvard Pedersen
- Department of Forensic Medicine, Unit of Anthropology (ADBOU), University of Southern Denmark
- Sabin-Christin Kornell
- Institute of Clinical Molecular Biology, Kiel University
- Dmitriy Drichel
- Department of Statistical Genetics and Bioinformatics, Cologne Center for Genomics (CCG), University of Cologne
- Marion Bonazzi
- Institute of Clinical Molecular Biology, Kiel University
- Lena Möbus
- Institute of Clinical Molecular Biology, Kiel University
- Peter Tarp
- Department of Forensic Medicine, Unit of Anthropology (ADBOU), University of Southern Denmark
- Julian Susat
- Institute of Clinical Molecular Biology, Kiel University
- Esther Bosse
- Institute of Clinical Molecular Biology, Kiel University
- Beatrix Willburger
- DKMS
- Alexander H. Schmidt
- DKMS
- Jürgen Sauter
- DKMS
- Andre Franke
- Institute of Clinical Molecular Biology, Kiel University
- Michael Wittig
- Institute of Clinical Molecular Biology, Kiel University
- Amke Caliebe
- Institute of Medical Informatics and Statistics, Kiel University
- Michael Nothnagel
- Department of Statistical Genetics and Bioinformatics, Cologne Center for Genomics (CCG), University of Cologne
- Stefan Schreiber
- Institute of Clinical Molecular Biology, Kiel University
- Jesper L. Boldsen
- Department of Forensic Medicine, Unit of Anthropology (ADBOU), University of Southern Denmark
- Tobias L. Lenz
- Department of Evolutionary Ecology, Research Group for Evolutionary Immunogenomics, Max Planck Institute for Evolutionary Biology
- Almut Nebel
- Institute of Clinical Molecular Biology, Kiel University
- DOI
- https://doi.org/10.1038/s41467-018-03857-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Leprosy, caused by infection with Mycobacterium leprae, was common in Europe in the Middle Ages. Here, Krause-Kyora et al. analyze ancient DNA from a medieval Danish leprosarium to assemble 10 complete bacterial genomes and perform association analysis of the DRB1*15:01 allele with risk of leprosy infection.
