Nature Communications (May 2017)
Thermogenetic neurostimulation with single-cell resolution
- Yulia G. Ermakova,
- Aleksandr A. Lanin,
- Ilya V. Fedotov,
- Matvey Roshchin,
- Ilya V. Kelmanson,
- Dmitry Kulik,
- Yulia A. Bogdanova,
- Arina G. Shokhina,
- Dmitry S. Bilan,
- Dmitry B. Staroverov,
- Pavel M. Balaban,
- Andrei B. Fedotov,
- Dmitry A. Sidorov-Biryukov,
- Evgeny S. Nikitin,
- Aleksei M. Zheltikov,
- Vsevolod V. Belousov
Affiliations
- Yulia G. Ermakova
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Aleksandr A. Lanin
- Physics Department, International Laser Center, M.V. Lomonosov Moscow State University
- Ilya V. Fedotov
- Physics Department, International Laser Center, M.V. Lomonosov Moscow State University
- Matvey Roshchin
- Institute of Higher Nervous Activity and Neurophysiology
- Ilya V. Kelmanson
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Dmitry Kulik
- Physics Department, International Laser Center, M.V. Lomonosov Moscow State University
- Yulia A. Bogdanova
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Arina G. Shokhina
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Dmitry S. Bilan
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Dmitry B. Staroverov
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Pavel M. Balaban
- Institute of Higher Nervous Activity and Neurophysiology
- Andrei B. Fedotov
- Physics Department, International Laser Center, M.V. Lomonosov Moscow State University
- Dmitry A. Sidorov-Biryukov
- Physics Department, International Laser Center, M.V. Lomonosov Moscow State University
- Evgeny S. Nikitin
- Institute of Higher Nervous Activity and Neurophysiology
- Aleksei M. Zheltikov
- Physics Department, International Laser Center, M.V. Lomonosov Moscow State University
- Vsevolod V. Belousov
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- DOI
- https://doi.org/10.1038/ncomms15362
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Current approaches to thermogenetic manipulation of neuronal activity lack sufficient spatiotemporal resolution. Here the authors show that neurons expressing snake TRPA1 channels are activated at high temporal resolution with IR light and this technique can be used to elicit behaviour in zebrafish larvae.
