Nature Communications (Jan 2022)
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation
- Haibo Wu,
- Peiqi He,
- Yong Ren,
- Shiqi Xiao,
- Wei Wang,
- Zhenbang Liu,
- Heng Li,
- Zhe Wang,
- Dingyu Zhang,
- Jun Cai,
- Xiangdong Zhou,
- Dongpo Jiang,
- Xiaochun Fei,
- Lei Zhao,
- Heng Zhang,
- Zhenhua Liu,
- Rong Chen,
- Weiqing Li,
- Chaofu Wang,
- Shuyang Zhang,
- Jiwei Qin,
- Björn Nashan,
- Cheng Sun
Affiliations
- Haibo Wu
- Department of Pathology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Peiqi He
- CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Yong Ren
- Department of Pathology, the First Hospital Affiliated to Army Medical University
- Shiqi Xiao
- Department of Pathology, the First Hospital Affiliated to Army Medical University
- Wei Wang
- Department of Pathology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Zhenbang Liu
- CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Heng Li
- Department of Pathology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Zhe Wang
- Department of Pathology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Dingyu Zhang
- Wuhan Jinyintan Hospital
- Jun Cai
- Shanghai Jiaotong University School of Medicine
- Xiangdong Zhou
- Third Military Medical University Daping Hospital
- Dongpo Jiang
- Third Military Medical University Daping Hospital
- Xiaochun Fei
- Shanghai Jiaotong University School of Medicine
- Lei Zhao
- Shanghai Jiaotong University School of Medicine
- Heng Zhang
- Shanghai Jiaotong University School of Medicine
- Zhenhua Liu
- Shanghai Jiaotong University School of Medicine
- Rong Chen
- Wuhan Jinyintan Hospital
- Weiqing Li
- Department of Critical Care Medicine, Key Laboratory of Emergency and Critical Care Research, Jinling Hospital, Nanjing University
- Chaofu Wang
- Shanghai Jiaotong University School of Medicine
- Shuyang Zhang
- Peking Union Medical College Hospital
- Jiwei Qin
- Transplant & Immunology Laboratory, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Björn Nashan
- Transplant & Immunology Laboratory, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China
- Cheng Sun
- CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- DOI
- https://doi.org/10.1038/s41467-021-27723-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Postmortem analyses provide useful information for COVID-19 etiology. Here the authors profile 22 deceased severe COVID-19 patients with transcriptomic and histological approaches to find correlations between the presence of viral antigens with lymphocyte suppression yet myeloid activation, hinting distinct functions of these cells during pathogenesis.
