Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy

Marc Aragó; Sergio Rodríguez-Arévalo; Petra Hyrossova; Juan Moreno; Sònia Abás; Agnès Figueras; Belén Pérez; Francesc Viñals; María Carmen Escolano; José Carlos Perales

doi:10.3390/proceedings2019022079

Proceedings (Aug 2019)

Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy

Marc Aragó,
Sergio Rodríguez-Arévalo,
Petra Hyrossova,
Juan Moreno,
Sònia Abás,
Agnès Figueras,
Belén Pérez,
Francesc Viñals,
María Carmen Escolano,
José Carlos Perales

Affiliations

Marc Aragó: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain
Sergio Rodríguez-Arévalo: Department of Pharmacology and Medicinal Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain
Petra Hyrossova: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain
Juan Moreno: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain
Sònia Abás: Department of Pharmacology and Medicinal Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain
Agnès Figueras: Institut D'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L’Hospitalet de Llobregat, Spain
Belén Pérez: Farmacologia Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
Francesc Viñals: Institut D'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L’Hospitalet de Llobregat, Spain
María Carmen Escolano: Department of Pharmacology and Medicinal Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain
José Carlos Perales: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain

DOI: https://doi.org/10.3390/proceedings2019022079
Journal volume & issue: Vol. 22, no. 1
p. 79

Abstract

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Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]

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Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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