Nature Communications (Sep 2022)
SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus
- Emilie Branche,
- Ying-Ting Wang,
- Karla M. Viramontes,
- Joan M. Valls Cuevas,
- Jialei Xie,
- Fernanda Ana-Sosa-Batiz,
- Norazizah Shafee,
- Sascha H. Duttke,
- Rachel E. McMillan,
- Alex E. Clark,
- Michael N. Nguyen,
- Aaron F. Garretson,
- Jan J. Crames,
- Nathan J. Spann,
- Zhe Zhu,
- Jeremy N. Rich,
- Deborah H. Spector,
- Christopher Benner,
- Sujan Shresta,
- Aaron F. Carlin
Affiliations
- Emilie Branche
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Ying-Ting Wang
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Karla M. Viramontes
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Joan M. Valls Cuevas
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Jialei Xie
- Department of Medicine, School of Medicine, University of California, San Diego
- Fernanda Ana-Sosa-Batiz
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Norazizah Shafee
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Sascha H. Duttke
- School of Molecular Biosciences, College of Veterinary Medicine, Washington State University
- Rachel E. McMillan
- Department of Medicine, School of Medicine, University of California, San Diego
- Alex E. Clark
- Department of Medicine, School of Medicine, University of California, San Diego
- Michael N. Nguyen
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Aaron F. Garretson
- Department of Medicine, School of Medicine, University of California, San Diego
- Jan J. Crames
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Nathan J. Spann
- Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego
- Zhe Zhu
- Department of Medicine, Division of Regenerative Medicine, University of California San Diego
- Jeremy N. Rich
- Department of Medicine, Division of Regenerative Medicine, University of California San Diego
- Deborah H. Spector
- Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego
- Christopher Benner
- Department of Medicine, School of Medicine, University of California, San Diego
- Sujan Shresta
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
- Aaron F. Carlin
- Department of Medicine, School of Medicine, University of California, San Diego
- DOI
- https://doi.org/10.1038/s41467-022-33041-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expression of inflammation- and metabolism-related genes to modulate DC functions.
