The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis

Pietro Di Fazio; Regine Schneider-Stock; Daniel Neureiter; Kinya Okamoto; Till Wissniowski; Susanne Gahr; Karl Quint; Matthias Meissnitzer; Beate Alinger; Roberta Montalbano; Gabriele Sass; Bernd Hohenstein; Eckhart G. Hahn; Matthias Ocker

doi:10.3233/CLO-2010-0511

Cellular Oncology (Jan 2010)

The Pan-Deacetylase Inhibitor Panobinostat Inhibits Growth of Hepatocellular Carcinoma Models by Alternative Pathways of Apoptosis

Pietro Di Fazio,
Regine Schneider-Stock,
Daniel Neureiter,
Kinya Okamoto,
Till Wissniowski,
Susanne Gahr,
Karl Quint,
Matthias Meissnitzer,
Beate Alinger,
Roberta Montalbano,
Gabriele Sass,
Bernd Hohenstein,
Eckhart G. Hahn,
Matthias Ocker

Affiliations

Pietro Di Fazio: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Regine Schneider-Stock: Department of Pathology, University Hospital Erlangen, Erlangen, Germany
Daniel Neureiter: Institute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, Austria
Kinya Okamoto: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Till Wissniowski: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Susanne Gahr: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Karl Quint: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Matthias Meissnitzer: Institute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, Austria
Beate Alinger: Institute of Pathology, Salzburger Landeskliniken, Paracelsus Private Medical University, Salzburg, Austria
Roberta Montalbano: Dipartimento di Scienze Biochimiche, Universita di Palermo, Policlinico, Palermo, Italy
Gabriele Sass: Division of Experimental Immunology and Hepatology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Bernd Hohenstein: Department of Medicine 4, University Hospital Erlangen, Erlangen, Germany
Eckhart G. Hahn: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany
Matthias Ocker: Department of Medicine 1, University Hospital Erlangen, Erlangen, Germany

DOI: https://doi.org/10.3233/CLO-2010-0511
Journal volume & issue: Vol. 32, no. 4
pp. 285 – 300

Abstract

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Inhibition of deacetylases represents a new treatment option for human cancer diseases. We applied the novel and potent pan-deacetylase inhibitor panobinostat (LBH589) to human hepatocellular carcinoma models and investigated by which pathways tumor cell survival is influenced.

Published in Cellular Oncology

ISSN: 1570-5870 (Print); 1875-8606 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Science: Biology (General): Cytology
Website: https://onlinelibrary.wiley.com/journal/2641

About the journal