The Use of Radiofrequency Thermal Ablation in Combine Treatment of Patients with Liver Bilobar Metastases from Colorectal Cancer

Abstract

Aim - determination of RFTA place in the combined treatment of bilobar liver metastatic process of colorectal cancer. Materials and methods. 176 patients with colorectal cancer with multiple (more than 4) bilobar liver metastases were included in the study after primary tumor removal. The research was held in Samara Regional Oncology Centre from 2001 to 2014. According to the treatment method patients were divided into two groups. Main group got the combined (chemotherapy + RFTA) treatment (98 patients). In control group only chemotherapy was applied to 78 patients. Results. One-, two- and three-year OS were 73.5%, 25.1%, 7.2% in the main group and 39.6%, 6.3%, 2.1% in the control group. With RFTA application we reached the 1.8% index of four-year survival in the main group, while three-year survival in the control group was only 2.1%. The OS median reached 18 months in the main group and 11 months in the control group, OS curves in two comparing groups were significantly different( log-rank test 3.77, р=0,000). Conclusion. Combination of RFTA with chemotherapy as the treatment of bilobar liver metastases of colorectal cancer, significantly improves the DFS and overall survival indexes, comparing to the group of patients who received only chemotherapy.

Keywords

• colorectal cancer
• combined treatment
• radiofrequency thermal ablation
• bilobarmethastastes