Nature Communications (Feb 2018)
A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle
- Benjamin Goode,
- Gourish Mondal,
- Michael Hyun,
- Diego Garrido Ruiz,
- Yu-Hsiu Lin,
- Jessica Van Ziffle,
- Nancy M. Joseph,
- Courtney Onodera,
- Eric Talevich,
- James P. Grenert,
- Iman H. Hewedi,
- Matija Snuderl,
- Daniel J. Brat,
- Bette K. Kleinschmidt-DeMasters,
- Fausto J. Rodriguez,
- David N. Louis,
- William H. Yong,
- M. Beatriz Lopes,
- Marc K. Rosenblum,
- Nicholas Butowski,
- Tarik Tihan,
- Andrew W. Bollen,
- Joanna J. Phillips,
- Arun P. Wiita,
- Iwei Yeh,
- Matthew P. Jacobson,
- Boris C. Bastian,
- Arie Perry,
- David A. Solomon
Affiliations
- Benjamin Goode
- Department of Pathology, University of California
- Gourish Mondal
- Department of Pathology, University of California
- Michael Hyun
- Department of Pathology, University of California
- Diego Garrido Ruiz
- Department of Pharmaceutical Chemistry, University of California
- Yu-Hsiu Lin
- Department of Laboratory Medicine, University of California
- Jessica Van Ziffle
- Department of Pathology, University of California
- Nancy M. Joseph
- Department of Pathology, University of California
- Courtney Onodera
- Clinical Cancer Genomics Laboratory, University of California
- Eric Talevich
- Clinical Cancer Genomics Laboratory, University of California
- James P. Grenert
- Department of Pathology, University of California
- Iman H. Hewedi
- Department of Pathology, Faculty of Medicine, Ain Shams University
- Matija Snuderl
- Departments of Pathology and Neurology, NYU Langone Medical Center
- Daniel J. Brat
- Department of Pathology, Northwestern University Feinberg School of Medicine
- Bette K. Kleinschmidt-DeMasters
- Department of Pathology, University of Colorado at Denver
- Fausto J. Rodriguez
- Department of Pathology, Johns Hopkins University School of Medicine
- David N. Louis
- Department of Pathology, Massachusetts General Hospital, Harvard Medical School
- William H. Yong
- Department of Pathology, David Geffen School of Medicine, University of California
- M. Beatriz Lopes
- Department of Pathology, University of Virginia School of Medicine
- Marc K. Rosenblum
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Nicholas Butowski
- Department of Neurological Surgery, University of California
- Tarik Tihan
- Department of Pathology, University of California
- Andrew W. Bollen
- Department of Pathology, University of California
- Joanna J. Phillips
- Department of Pathology, University of California
- Arun P. Wiita
- Department of Pharmaceutical Chemistry, University of California
- Iwei Yeh
- Department of Pathology, University of California
- Matthew P. Jacobson
- Department of Pharmaceutical Chemistry, University of California
- Boris C. Bastian
- Department of Pathology, University of California
- Arie Perry
- Department of Pathology, University of California
- David A. Solomon
- Department of Pathology, University of California
- DOI
- https://doi.org/10.1038/s41467-018-02826-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Chordoid glioma is a rare low-grade brain tumor that originates from the anterior wall of the third ventricle where surgical resection is challenging; the clinical outcome of patients after subtotal resection or disease recurrence is poor. Here the authors identify a recurrent missense mutation in PRKCA that may serve as a potential therapeutic target in this uncommon brain cancer.
