Nature Communications (May 2022)
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling
- Maria Thürmer,
- André Gollowitzer,
- Helmut Pein,
- Konstantin Neukirch,
- Elif Gelmez,
- Lorenz Waltl,
- Natalie Wielsch,
- René Winkler,
- Konstantin Löser,
- Julia Grander,
- Madlen Hotze,
- Sönke Harder,
- Annika Döding,
- Martina Meßner,
- Fabiana Troisi,
- Maximilian Ardelt,
- Hartmut Schlüter,
- Johanna Pachmayr,
- Óscar Gutiérrez-Gutiérrez,
- Karl Lenhard Rudolph,
- Kathrin Thedieck,
- Ulrike Schulze-Späte,
- Cristina González-Estévez,
- Christian Kosan,
- Aleš Svatoš,
- Marcel Kwiatkowski,
- Andreas Koeberle
Affiliations
- Maria Thürmer
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- André Gollowitzer
- Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Helmut Pein
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Konstantin Neukirch
- Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Elif Gelmez
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Lorenz Waltl
- Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Natalie Wielsch
- Research Group Mass Spectrometry and Proteomics, Max Planck Institute for Chemical Ecology
- René Winkler
- Department of Biochemistry, Center for Molecular Biomedicine (CMB), Friedrich-Schiller-University Jena
- Konstantin Löser
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Julia Grander
- Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck
- Madlen Hotze
- Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck
- Sönke Harder
- Institute of Clinical Chemistry and Laboratory Medicine, Section Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf
- Annika Döding
- Section of Geriatric Dentistry, Center of Dental Medicine, University Hospital Jena, Friedrich-Schiller-University Jena
- Martina Meßner
- Department of Pharmacy, Pharmaceutical Biology, LMU Munich
- Fabiana Troisi
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- Maximilian Ardelt
- Department of Pharmacy, Pharmaceutical Biology, LMU Munich
- Hartmut Schlüter
- Institute of Clinical Chemistry and Laboratory Medicine, Section Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf
- Johanna Pachmayr
- Department of Pharmacy, Pharmaceutical Biology, LMU Munich
- Óscar Gutiérrez-Gutiérrez
- Leibniz Institute on Aging—Fritz Lipmann Institute (FLI)
- Karl Lenhard Rudolph
- Research Group on Stem Cell Aging, Leibniz Institute on Aging—Fritz Lipmann Institute (FLI)
- Kathrin Thedieck
- Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck
- Ulrike Schulze-Späte
- Section of Geriatric Dentistry, Center of Dental Medicine, University Hospital Jena, Friedrich-Schiller-University Jena
- Cristina González-Estévez
- Leibniz Institute on Aging—Fritz Lipmann Institute (FLI)
- Christian Kosan
- Department of Biochemistry, Center for Molecular Biomedicine (CMB), Friedrich-Schiller-University Jena
- Aleš Svatoš
- Research Group Mass Spectrometry and Proteomics, Max Planck Institute for Chemical Ecology
- Marcel Kwiatkowski
- Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck
- Andreas Koeberle
- Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena
- DOI
- https://doi.org/10.1038/s41467-022-30374-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Fatty acid unsaturation by stearoyl-CoA desaturase 1 (SCD1) protects against cellular stress through unclear mechanisms. Here the authors show 1,2-dioleoyl-sn-glycero-3-phospho-(1’-myo-inositol) is an SCD1-derived signaling lipid that regulates stress-adaption, protects against cell death and promotes proliferation.
