Nature Communications (Jul 2018)

ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

  • Somaira Nowsheen,
  • Khaled Aziz,
  • Kuntian Luo,
  • Min Deng,
  • Bo Qin,
  • Jian Yuan,
  • Karthik B. Jeganathan,
  • Jia Yu,
  • Henan Zhang,
  • Wei Ding,
  • Jan M. van Deursen,
  • Zhenkun Lou

DOI
https://doi.org/10.1038/s41467-018-05161-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response.