The Roles of Long Non-coding RNAs in Osteogenic Differentiation and Bone Diseases

Abstract

Bone marrow mesenchymal stem cells play an important role in osteogenic differentiation, and they complete this important biological process through the coordination of various transcription factors and signal pathways. In recent years, studies have clearly confirmed that long non-coding RNAs (lncRNAs) are involved in osteogenic differentiation, which plays an important biological role in the occurrence and development of osteogenesis-related bone disease. This article reviews the roles and related mechanisms of lncRNAs in osteogenic differentiation, as well as their potential effects on a variety of bone diseases. This understanding may help researchers identify potential therapeutic targets and biological markers in the future.

Keywords

• long non-coding rna
• osteogenesis differentiation
• osteosarcoma
• osteoarthritis
• osteoporosis