Nature Communications (Nov 2021)

Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis

  • Alison E. Jarmas,
  • Eric W. Brunskill,
  • Praneet Chaturvedi,
  • Nathan Salomonis,
  • Raphael Kopan

DOI
https://doi.org/10.1038/s41467-021-26626-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The cessation of nephrogenesis determines nephron endowments in mammals. Here the authors show that differential translation of Wnt antagonists versus agonists determines the tipping point from self-renewal to differentiation of nephron progenitors during nephrogenesis, using mutant mice with elevated nephron numbers.