6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine

Abstract

We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with 1H/13C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS).

Keywords

• 2-methyl-2<i>h</i>-1,2,3-triazole
• 4-anilino-quin(az)olines
• conformational flexibility
• hinge binder
• kinase inhibitor design