Memorias do Instituto Oswaldo Cruz (Jan 1987)

Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms

  • D. G. Colley,
  • J. C. Parra,
  • M. A. Montesano,
  • M. Lima,
  • E. Nascimento,
  • B. L. Doughty,
  • A. Goes,
  • G. Gazzinelli

DOI
https://doi.org/10.1590/S0074-02761987000800017
Journal volume & issue
Vol. 82
pp. 105 – 109

Abstract

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Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.