Nature Communications (Apr 2019)
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα
- Ning Liang,
- Anastasius Damdimopoulos,
- Saioa Goñi,
- Zhiqiang Huang,
- Lise-Lotte Vedin,
- Tomas Jakobsson,
- Marco Giudici,
- Osman Ahmed,
- Matteo Pedrelli,
- Serena Barilla,
- Fawaz Alzaid,
- Arturo Mendoza,
- Tarja Schröder,
- Raoul Kuiper,
- Paolo Parini,
- Anthony Hollenberg,
- Philippe Lefebvre,
- Sven Francque,
- Luc Van Gaal,
- Bart Staels,
- Nicolas Venteclef,
- Eckardt Treuter,
- Rongrong Fan
Affiliations
- Ning Liang
- Department of Biosciences and Nutrition, Karolinska Institutet
- Anastasius Damdimopoulos
- Department of Biosciences and Nutrition, Karolinska Institutet
- Saioa Goñi
- Department of Biosciences and Nutrition, Karolinska Institutet
- Zhiqiang Huang
- Department of Biosciences and Nutrition, Karolinska Institutet
- Lise-Lotte Vedin
- Department of Laboratory Medicine, Karolinska Institutet
- Tomas Jakobsson
- Department of Laboratory Medicine, Karolinska Institutet
- Marco Giudici
- Department of Biosciences and Nutrition, Karolinska Institutet
- Osman Ahmed
- Department of Laboratory Medicine, Karolinska Institutet
- Matteo Pedrelli
- Department of Laboratory Medicine, Karolinska Institutet
- Serena Barilla
- Department of Biosciences and Nutrition, Karolinska Institutet
- Fawaz Alzaid
- INSERM, Cordeliers Research Centre, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot
- Arturo Mendoza
- Division of Endocrinology, Diabetes and Metabolism, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medicine
- Tarja Schröder
- Department of Laboratory Medicine, Karolinska Institutet
- Raoul Kuiper
- Department of Laboratory Medicine, Karolinska Institutet
- Paolo Parini
- Department of Laboratory Medicine, Karolinska Institutet
- Anthony Hollenberg
- Division of Endocrinology, Diabetes and Metabolism, Joan & Sanford I. Weill Department of Medicine, Weill Cornell Medicine
- Philippe Lefebvre
- University Lille, INSERM, CHU Lillie, Institut Pasteur de Lille, U1011-EGID
- Sven Francque
- Department of Gastroenterology and Hepatology, University of Antwerp
- Luc Van Gaal
- Laboratory of Experimental Medicine and Pediatrics, University of Antwerp
- Bart Staels
- University Lille, INSERM, CHU Lillie, Institut Pasteur de Lille, U1011-EGID
- Nicolas Venteclef
- INSERM, Cordeliers Research Centre, Sorbonne Paris Cité, Université Paris Descartes, Université Paris Diderot
- Eckardt Treuter
- Department of Biosciences and Nutrition, Karolinska Institutet
- Rongrong Fan
- Department of Biosciences and Nutrition, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-09524-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Dysregulation of PPARα dependent fatty acid oxidation promotes hepatic steatosis. Here the authors show that GPS2 inhibits PPARα activity and that ablation of GPS2 ameliorates hepatic steatosis in mice.
